CDH1/E Cadherin Antibody LS-C338688 Mouse Monoclonal Human CDH1. WB Available as HRP, FITC, PE, Agarose and multiple (6) AlexaFluor® conjugates. Cited in 140 publications A negative E-cadherin stain was a sensitive and specific biomarker to confirm the diagnosis of invasive lobular carcinoma (specificity 97.7%; negative predictive value 96.8%; sensitivity 88.1%; and positive predictive value 91.2%). Positive E-cadherin expression was also associated with tubulolobular carcinomas Epithelial cadherin (E-cadherin) is a transmembrane protein ( Histopathology 2016;68:57 ) Extracellular domain involved in intercellular adhesion and polarity maintenance. Cytoplasmic domain attached to actin units α / γ / β- and p120 catenins. Encoded by CDH1 (CaDHerin-1) gene located on chromosome 16 (16q22.1 The majority of all carcinomas were estrogen and progesterone receptor positive. E-cadherin displayed membranous staining in all tubular and tubulolobular carcinomas, and was negative in all lobular carcinomas. Half of each carcinoma subtype displayed granular cytoplasmic 34betaE12 immunoreactivity. alpha-Catenin exhibited partial or complete.
Differences in percentages of E-cadherin-positive cases between the primary and metastatic groups were tested for statistical significance using Fisher's exact test. P < 0.05 was considered significant. A two-sample t test was also performed to compare the size, the ER, PR and HER-2/neu status, and the E-cadherin expression E-cadherin Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-246S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldric E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E.
E-cadherin (epithelial calcium-dependent adhesion protein) is a transmembrane protein expressed primarily in epithelial cells. 1 In normal epithelial tissues, e-cadherin acts to establish and maintain cell-to-cell adhesion and is also a central player in the morphogenesis of cells during migration. 2 Because its expression pattern is limited to cells of epithelial origin, E-cadherin is. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with breast cancer. Even though the expression of E-cadherin has been studied in primary breast tumors, little is known about its expression at the distant metastatic sites. We investigate the relationship between E-cadherin expression in primary breast carcinoma and their distant, non-nodal.
E-Cadherin Positive Control. Product no.: PC-ECAD. Be the first to rate this product. $185.00. Shipping Options. Bulk and Special Orders Quote. Add to cart. Recommend 2 Responses. japdip. E-Cadherin (protein) when found overexpressed (positive) is an indicator of a greater possibility of distant metastises of breast cancer. Any further explanation would be much too complicated to be understood completely The E-cadherin-positive cells were of different shapes and, from their appearance, two types of E-cadherin-positive cells were recognised. Type I E-cadherin-positive cells were represented by elongated, spindle-like cells which typically, were longitudinally orientated along the arterial lumen (Fig. 1B, C) The median survival for patients with intact e-cadherin labeling was 18.5 months, and the median survival for those with loss of e-cadherin labeling was 12.1 months (p=0.005, log-rank test). B) Patient survival according to e-cadherin expression classified as intact vs. partial loss, vs. total loss of expression E-cadherin, a cell surface protein involved in cell adhesion, is present in normal breast epithelium, benign breast lesions, and in breast carcinoma. Alterations in the gene CDH1 on chromosome 16q22 are associated with changes in E-cadherin protein expression and function. Inactivation of E-cadherin in lobular carcinomas and certain diffuse gastric carcinomas may play a role in the dispersed.
The E-cadherin-catenin complex plays a key role in cellular adhesion; loss of this function has been associated with increased invasiveness and metastasis of tumors. The suppression of E-cadherin expression is regarded as one of the main molecular events responsible for dysfunction in cell-cell adhesion, which can lead to local invasion and. . From 77 tumor entities derived from cell types normally positive for E-Cadherin, 35 (45.5%) retained at least a weak E-Cadherin immunostaining in ≥99% of cases and 61 (79.2%) in ≥90% of cases Other cancers. Somatic CDH1 gene mutations are also associated with an increased risk of other cancers, including cancers of the lining of the uterus (endometrium) or the ovaries in women, and prostate cancer in men. These CDH1 gene mutations are thought to result in a nonfunctional E-cadherin protein. A loss of functional E-cadherin in these cells prevents tumor suppression and cell adhesion.
E-cadherin, significant correlation was observed between the immunopositivity and TNM stages IA+IB. P53-negative patients had significantly better outcomes than p53-positive patients. Significant association between expression of E-cadherin and histologic types was found in familial, but not in sporadic, EOGC A hallmark of EMT is the switch from E‐ to N‐cadherin. 3 E‐cadherin is a molecule that mediates homophilic cell‐cell adhesion and tissue homeostasis in normal epithelia, 4 and it has been shown to suppress invasion in many tumor cell types. 5, 6 Unlike E‐cadherin, another member of the cadherin superfamily, N‐cadherin seems to be. To assess confirmed response rate by RECIST 1.1 of crizotinib and fulvestrant in advanced E-cadherin negative, ER positive lobular breast cancer. Percentage of Basket Cohort Participants With Objective Response Assessed Using RECIST v1.1 [ Time Frame: From Day 1 to Progressive Disease, assessed up to end of study (up to approximately 48 months) E-cadherin expression in INFPAs was lower than that in NNFPAs. N-cadherin was positive or strongly positive in both groups. Spearman's correlation analysis showed that the expression of IL-6 and STAT3 was positively correlated with Knosp's classification, whereas the expression of E-cadherin was negatively correlated with Knosp classification
E-cadherin was positive in all cases. All epithelial cells of the normal terminal duct-lobular unit were stained with moderate intensity, and the final reaction produc The xenograft model in which E-cadherin negative MDA-MB-231 cells formed E-cadherin-negative primary tumors in the mammary fat pads but E-cadherin-positive micrometastases and the finding that at least some E-cadherin-negative primary breast carcinoma cells can re-express this molecule support the idea that this reversion is possible DISCUSSION 1. Comparison of age distribution with e cadherin and vimentin. The age group of patients included in our study varied from less than 40yrs to more than 80 yrs with most patients belonging to the age group of 61-70 yrs. 18 out of 50 cases contributing to 36% belong to the age group 61- 70 yrs and the mean age being 56.99 yrs.out of 18 cases 9 were e cadherin positive (26.47%) and 9. SPARC, E-cadherin, and EZH2. We found that the relative mRNA and protein levels of SPARC and E-cadherin were strongly downregulated, but EZH2 was markedly upregulated in EC compared with the PPE tissues. The abnormal SPARC, E-cadherin, and EZH2 expressions were correlated with the FIGO stage, grade, and poor clinical outcomes
Anti-E Cadherin antibody [EP700Y] - Intercellular Junction Marker (ab40772) at 1/200000 dilution (Unpurified) + MCF7 (Human breast adenocarcinoma ) whole cell lysates at 20 µg. Secondary. Goat Anti-Rabbit IgG H&L (HRP) at 1/1000 dilution. Predicted band size: 97 kDa 5.2. E-cadherin to P-cadherin Switching and Tubular Elements. In 1979, Martinez and Azzopardi emphasized that some ILCs display focal tubules . Meanwhile, so-called tubulolobular BC has been disqualified as an E-cadherin-positive variant of ductal BC (id est, a mimic of ILC) [237,238,239,240] E-cadherin staining was not subtle, and easily scored as either positive or negative, with no disagreements between the cytotechnologist and the pathologist. The summary of E-cadherin scoring of all the cases is shown in Table 2, split by cytologic diagnosis. Although most cases (28 of 32) that were malignant had E-cadherin staining, 4 cases. By day 7, PanINs stained partially positive for E-cadherin, showed structural abnormalities, and exhibited decreased amylase and increased cytokeratin-19. Within a similar time frame, pancreatic tissue began to adhere to the intestine, resulting in ascites and death. No metastases to other organs were observed E-cadherin control slides contain sections of positive staining ductal breast carcinoma and negative staining myometrium.VWR offers slides for the varied purposes of your lab. Prepared and digital microscope slides for educational purposes are featured in an array of fields. General purpose microscope slides and cover glasses are offered as well as cavity, chamber, adhesion, and microarray.
Anti-E-cadherin Antibody (G-10) is a mouse monoclonal IgG 1 κ E-cadherin antibody, cited in 451 publications, provided at 200 µg/ml. raised against amino acids 600-707 mapping within the extracellular domain of E-cadherin of human origin. Anti-E-cadherin Antibody (G-10) is recommended for detection of E-cadherin of mouse, rat and human origin. CD324 (E-Cadherin) Antibody (14-3249-82) in WB. Immunoblot analysis of reduced MDCK cell line lysates with 2 µg/mL of Anti-Human CD324 (E-Cadherin) Purified and revealed with Anti-Rat IgG HRP. Lane 1: EDTA treated cells and Lane 2: Trypsin treated cells to remove from tissue culture dish
In normal conditions they should be E-cadherin positive but my BEAS-2B aren't. I keep them on MEM medium with 0.5% FCS in a 5%CO2 incubator. I tried them on a coated flask (fibronectin/collagen. The HR for E-cadherin 1 þ vs E-cadherin 0 was 1.04 significant amounts of E-cadherin and just a small amount of (P ¼ 0.88), for E-cadherin 2 þ vs E-cadherin 1 þ was 0.62 (P ¼ 0.22) N-cadherin, increase their motility and that a forced expression of and for E-cadherin 3 þ vs E-cadherin 2 þ was 2.94 (P ¼ 0.03) Anti-E Cadherin antibody [EP700Y] - Intercellular Junction Marker (ab40772) Research with confidence - consistent and reproducible results with every batch. Long-term and scalable supply - powered by recombinant technology for fast production. Success from the first experiment - confirmed specificity through extensive validation E-cadherin expression was considered positive if the score was ≥ 2, and negative when score was ≤ 1. We considered a high Ki67 index > 20% [ 42 ]. This retrospective, non interventional study was conducted on archived tumor sections, for whom informed written consent was obtained from donors or the next of kin for the use of tumors sample.
Both lysosome inhibitors caused accumulation of E-cadherin vesicles, some of which were positive for Cathepsin D and lysosome-associated membrane protein 1 (LAMP-1) White arrows indicate E-cadherin positive cytoplasmic vesicles. (c) Quantification of number, intensity of fluorescence, and area of vesicles in HFK and shIRF6. A minimum of 50 cells were counted per group in three separate experiments. (d) Internalization of E-cadherin in HFK or shIRF6 cells 60 min after addition of E-cadherin antibody E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer E-cadherin is consistently (and definitionally) positive in tubulolobular carcinoma Demonstration of myoepithelial cells can confirm the in situ nature of a process while their absence supports invasion We prefer to use both p63 and calponin on problematic cases; A variety of markers have been used for myoepithelial cells The intestinal ecosystem is balanced by dynamic interactions between resident and incoming microbes, the gastrointestinal barrier, and the mucosal immune system. However, in the context of inflammatory bowel diseases (IBD), where the integrity of the gastrointestinal barrier is compromised, resident microbes contribute to the development and perpetuation of inflammation and disease. Probiotic.
E-cadherin positive ILCs were subjected to molecular analysis including comparative genomic hybridization. Different morphologic components of case 25, showing heterogenous E-cadherin expression, were analyzed by E-cadherin gene sequencing, methylation, and DASL gene expression profiling. Four ILCs were positive for E-cadherin, but each also. E-Cadherin status is to be considered negative if the H-score is less than or equal to the cutoff; if it is above the cutoff then the status is positive. Subsequent calculations determined that E-cadherin status had a weak correlation with the IVF outcome, which was statistically insignificant ( Figure 11; Table 4) Immunohistochemistry showed 30 cases with positive E-cadherin expression (41%), 10 cases with partially reduced E-cadherin expression (14%), and 33 cases with lack of E-cadherin expression (45%). A significant association was found between the results of immunohistochemistry and the CDH1 promoter methylation status (Table 1) ⇓. Also, patients. The positive E-cadherin expression was uniform and showed a homogeneous, fine glandular pattern (Fig. 1A) as in normal endometrium. In the heterogeneous staining pattern, only some part of the tumor showed positive staining or the cell-cell boundaries had a coarse, irregular, granular staining (Fig. 1B) Nuclear E-cadherin staining was not detected. p53 and Ki67 expression was not significantly higher in tumors with aberrant staining patterns for E-cadherin ( U test P >0.05). The combination of positive Ki67 in less than 5% of cells and normal E-cadherin expression was found in 5 of 17 tumors (pat. no. 4, 7, 8, 9, 17)
E-cadherin has been shown to trigger the intracellular PI3K-AKT and ERK pathways, two prosurvival pathways. 52 Our findings confirmed that E-cadherin-positive tumor cells resist death by activating overall canonical survival-related kinases, e.g., AKT, ERK, and JAK (Figs. 4 and 5). Interestingly, this signaling was modulated by the toxic. The role(s) of E-cadherin in tumor progression, invasion, and metastasis remains somewhat enigmatic. In order to investigate various aspects of E-cadherin biological activity, particularly in prostate cancer progression, our laboratory cloned unique subpopulations of the heterogeneous DU145 human prostatic carcinoma cell line and characterized their distinct biological functions An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancer. P Querzoli, 1, 7 D Coradini, 2, 7, * M Pedriali, 1 P Boracchi, 2 F Ambrogi, 2 E Raimondi, 2 R La Sorda, 3 R Lattanzio, 3 R Rinaldi, 1 M Lunardi, 1 C Frasson, 1 F Modesti, 1 S Ferretti, 1 M Piantelli, 3 S Iacobelli, 4 E. Epitope/Antigen:E-cadherin Positive Control:Breast cancer Cellular Localization:Cytoplasmic/membrane Normal Tissue:Colon, breast infiltrating ductal cell carcinoma, colon cancer Buffer with protein carrier and preservative. Total Protein Concentration:Call for lot specific Ig Concentration. Mouse monoclonal Species Reactivity:Human; others not.
Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate the molecular basis of this notion, we use two methods to inhibit E-cadherin function that distinguish between E-cadherin's cell-cell adhesion and intracellular signaling functions E-cadherin-positive cells (right) were grown at equal cell density to E-cadherin-negative cells (left), or to a lower density (middle) in order to better visualize cell colonies. The analysis was performed by immunofluorescence using mAbs against β-catenin and NF-κB. No signal was obtained when the same analysis was performed in the absence.
SANTA CRUZ BIOTECHNOLOGY, INC. E-cadherin (DECMA-1): sc-59778 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com BACKGROUND Cadherins comprise a family of Ca2+-dependent adhesion molecules that func- tion to mediate cell-cell binding critical to the maintenance of tissue structur Evaluation (scoring) of E-cadherin staining The intensity of E-cadherin was read semi-quantitatively based on the immunostaining intensity and the percentage of E-cadherin-positive cells. Based on the Allred scoring system, 4 categories of staining (0, 1, 2, and 3) ranging from none (negative) to strong were used
A p 53, Cerb2, Her2 negatív. Az E-cadherin pozitív membrán rakciót ad, a ductális eredet alátaámasztva. Összefoglalva magas gradusu invasiv ductalis carcinomáról van szó, mely hormon receptor pozitív. Carcinoma ductale invasivum mammae, grade III., pT1c, pNS0, NPI=4, 3, mérsékelten jó prognózis GenScript E-Cadherin Antibody detects human and mouse endogenous levels of E-Cadherin. It is predicted to react with rat E-Cadherin protein according to sequence homology. Positive Control: HepG2 and NIH/3T3: Species Reactivity: Human and mouse: Storage: The antibody is stable in lyophilized form if stored at -20°C or below Perturbations in cell-cell contact machinery occur frequently in epithelial cancers and result in increased cancer cell migration and invasion. Previously, we demonstrated that MMP-7, a protease implicated in mammary and intestinal tumor growth, can process the adherens junction component E-cadherin. This observation leads us to test whether MMP-7 processing of E-cadherin could directly impact. the percentage of E-cadherin-positive cells. Based on the Allred scoring system, 4 categories of staining (0, 1, 2, and 3) ranging from none (negative) to strong were used. Zero (0) referred to negative/none with zero posi - tive cells, 1 - weak with < 1 positive cell, 2 - intermedi-ate with 1-10 positive cells, and 3 - strong with 11-3 The lack of E-cadherin in E-cadh-/-mES cells was confirmed by western blot, flow cytometry and genotyping (supplementary material Fig. S8B-D). Further characterization of these E-cadherin null cells revealed also that expression of pluripotency markers, such as SSEA-1, Nanog or Klf4, was absent or reduced (supplementary material Fig. S8D-F)
Immunohistochemistry for E-cadherin was performed in all 25 cases. Eleven cases (44%) were positive for E-cadherin (Figure 2). Thirteen cases (52%) showed mixed immunophenotype with positive E-cadherin staining the ductal cells and negative in the lobular areas. In one case, the cells were completely negative for E-cadherin pluripotent cells. E-cadherin was highly expressed in mouse embryonic stem cells, and interference with E-cadherin caused differentiation. During cellular reprogramming of mouse fibroblasts by Oct4, Sox2, Klf4 and c-Myc, fully reprogrammed cells were exclusively observed in the E-cadherin positive cel E-cadherin (epithelial-cadherin), encoded by the CDH1 gene, is a transmembrane glycoprotein playing a crucial role in maintaining cell-cell adhesion. E-cadherin has been reported to be a tumor suppressor and to be down regulated in gastric cancer. Besides genetic mutations in CDH1 gene to induce hereditary diffuse gastric cancer (HDGC), epigenetic factors such as DNA hypermethylation also.
Conclusion: E-Cadherin is consistently expressed in various epithelial cancers. Down-regulation or loss of E-Cadherin expression in cancers arising from E-Cadherin positive tissues as well as E-Cadherin neo-expression in cancers arising from E-Cadherin negative tissues is linked to cancer progression and may reflect tumor dedifferentiation INTRODUCTION. E-cadherin is a key cell-cell adhesion protein in epithelial cells. It is concentrated in adherens junctions at the lateral cell surface, where it mediates calcium-dependent, homotypic binding to cadherins on adjacent cells (Takeichi, 1991, 1995).E-cadherin function is required for morphogenesis, the maintenance of epithelial function, and as a tumor suppressor (Gumbiner, 1996. E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that encompasses an E-cadherin-dependent barrier, critical for the homeostasis of the organ
It is also reported that EGF induces the 6 scattering of E-cadherin positive CaSki cells. The study showed that the activation of EGFR 7 resulted in the phosphorylation of β- and γ-catenin in CaSki cells with positive E-cadherin 8 expression and altered function of catenins interfered with the adhesive function of E-cadherin 9 .. The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered CDH1 mutations, we identified synthetic lethality between E-cadherin deficiency and inhibition of the tyrosine kinase ROS1 A PLR of 21.10 indicates a 21.10-fold higher positive rate of E-cadherin in patients with malignant pleural effusions compared with in benign patients, suggesting that E-cadherin is clinically significant. The NLR was determined to be 0.17, indicating that the probability of malignant exudation of cadherin-negative patients was 17%..
P-cadherin ( CDH3 ), the classical myoepithelial cadherin ( Shamir and Ewald, 2015 ), is a target gene of Slug and mediates many of its functions ( Idoux-Gillet et al., 2018 ). E-cadherin is highly expressed in luminal cells, but Slug expressing basal cells also express E-cadherin ( Ye et al., 2015 ). E-cadherin localizes to the lateral cell. Product Specific Information. Description: The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion Immunoexpression of E-cadherin was reduced in EOC, while 100 % expression was seen in LMP tumors and benign cystadenomas. An interesting observation was the nuclear expression of E-cadherin in a high percentage of cancers, which showed a positive correlation with Ki-67 Positive ZEB-1 expression and loss of E-cadherin expression are correlated with poor prognosis in HCC patients and malignancy of ZEB-1 positive tumors involves EMT. While recent research has shown that expression of ZEB-1 in a variety of tumors has a crucial impact on patient survival, there is little information regarding ZEB-1 expression in. HPV Cervical Cancer E-cadherin HeLa Cells Oxamflatin 1. Background Cervical cancer is regarded as one of the most common causes of cancer-related deaths in women (), emphasizing the importance of investigating new treatment drugs for this malignancy ().It is estimated that 95% of cervical cancer cases are mediated by persistent high-risk human papillomavirus (HPV) infections (), encoding two.
P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. However, its behaviour in the malignant setting is notably dependent on the cellular context. In some tumour models, such as melanoma and oral squamous cell carcinoma, P-cadherin acts as a tumour suppressor, since its absence is associated with a more aggressive cancer cell phenotype. tween calmodulin and E-cadherin for binding to IQGAP1 both in vitro and in a normal cellular milieu. Immunocytochemical analysis in MCF-7 (E-cadherin positive) and MDA-MB-231 (E-cadherin negative) epithe-lial cells revealed that E-cadherin is required for accu-mulation of IQGAP1 at cell-cell junctions. The cell-per Meanwhile, a positive correlation of E-cadherin and CXCR3-B expression was found both in experimental PCa liver micro-metastases and patients' tissue. CXCR3-B and E-cadherin positively correlated in vitro and in vivo in PCa cells and liver metastases, whereas CXCR3-A negatively regulated E-cadherin expression
Purpose E-cadherin is a calcium-dependent glycoprotein whose main role is cell-cell adhesion. Its transcriptional repressor TWIST1 is a basic helix-loop-helix (bHLH) protein that participates in gastrulation and formation of mesodermal tissues during embryogenesis. In adult tissues, the high expression of TWIST1 induces the epithelial-mesenchymal transition (EMT)—a process in which. A decreased expression of E-Cadherin is associated with metastatic potential and poor prognosis in breast cancer and esophagus cancer. In combination with p120 Catenin or Cytokeratin it is useful for the differentiation between ductal (E-Cadherin positive) and lobular (E-Cadherin negative) breast carcinomas
Since the level of junctional N-cadherin remained unchanged, we can conclude that the mechanism of depletion is selective for E-cadherin, and does not act as a cadherin switch where downregulation of E-cadherin is accompanied by upregulation of N-cadherin as in epithelial-mesenchymal transition (Figs. 4, 8) (Wheelock et al., 2008) The E‐cadherin‐positive cell‐depleted fraction (nonparenchymal fraction) was washed twice with 10% FBS/DM‐160 by centrifugation, and resuspended in 10% FBS/DM‐160 containing 10 −7 m dexamethasone, 20 μg mL −1 heparin and antibiotics. This cell suspension was adjusted to the original volume before mixing with immunomagnetic beads Recombinant Anti-E-Cadherin Rabbit Monoclonal Antibody (10204-R032), manufactured by Sino Biological is validated in IHC-P,ICC/IF. Custom antibody services and bulk production also available. To learn more comprehensive our antibody product information including immunogen, specificity, and more, you can read all details here Figure 12. IF analysis of E Cadherin using anti-E Cadherin antibody (PB9561). E Cadherin was detected in paraffin-embedded section of mouse ileum organoid tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum E-Cadherin/Cadherin-1, also known as Uvomorulin in the mouse and rat, is a 120 kDa member of the Cadherin family of cell surface glycoproteins that mediate cell adhesion (1). Human E-Cadherin shares 81% amino acid sequence identity with the rat and mouse proteins (2). It is a single-pass transmembrane protein that mediates calcium-dependent.